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1. The "Nano-Knives" Would Slice the Animal's Cells Too A raw graphene sheet or carbon nanotube cannot distinguish between a fungal cell wall and a host cell membrane. If injected into an animal's bloodstream, these sharp nanomaterials physically puncture and damage the animal's own red blood cells, blood vessels, and internal organs. Studies show that uncontrolled multi-walled carbon nanotubes can actually suppress an animal’s immune system, making an infection worse rather than better.
2. Biological "Cloaking" (The Protein Corona) The moment any raw nanoparticle enters an animal's body fluid, it is instantly coated by host proteins (forming a "protein corona"). This biological coating dulls the sharp mechanical edges of materials like graphene, rendering their physical "slicing" mechanism useless before they ever reach the target cells.
3. Toxicity and Bioaccumulation Unlike chemical drugs that the liver and kidneys can break down and excrete, inorganic materials like graphene, carbon nanotubes, or titanium cannot be easily metabolized. They accumulate permanently in the animal’s spleen, liver, and lungs, triggering chronic inflammation and long-term tissue damage. [1]